Abstract #0087

Assessment of Free-Breathing Radial Magnetic Resonance Elastography in Healthy Children and Children with Liver Disease at 3T

Sevgi Gokce Kafali^1,2, Tess Armstrong¹, Shu-Fu Shih^1,2, Joseph L Holtrop³, Robert S Venick⁴, Shahnaz Ghahremani¹, Bradley D. Bolster Jr⁵, Claudia M. Hillenbrand³, Kara L. Calkins⁴, and Holden H. Wu^1,2

¹Radiological Sciences, University of California, Los Angeles, Los Angeles, CA, United States, ²Bioengineering, University of California, Los Angeles, Los Angeles, CA, United States, ³Diagnostic Imaging, St. Jude Children’s Research Hospital, Memphis, TN, United States, ⁴Pediatrics, University of California, Los Angeles, Los Angeles, CA, United States, ⁵Siemens Medical Solutions, Salt Lake City, UT, United States

Hepatic stiffness measured by magnetic resonance elastography (MRE) is a biomarker that correlates with histopathological staging of liver fibrosis. Conventional Cartesian gradient-echo MRE requires breath-holding (BH), which may be inconsistent and challenging for children. Free-breathing (FB) MRE based on radial acquisition is a promising solution to this problem. In this study, we investigated the agreement in hepatic stiffness values from BH-MRE and FB-MRE, as well as repeatability, in healthy children and pediatric patients at 3T. Bland-Altman analysis showed a high level of agreement between BH-MRE and FB-MRE, and repeatability analysis showed similar performance for BH-MRE and FB-MRE.

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