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Abstract #0087

Assessment of Free-Breathing Radial Magnetic Resonance Elastography in Healthy Children and Children with Liver Disease at 3T

Sevgi Gokce Kafali1,2, Tess Armstrong1, Shu-Fu Shih1,2, Joseph L Holtrop3, Robert S Venick4, Shahnaz Ghahremani1, Bradley D. Bolster Jr5, Claudia M. Hillenbrand3, Kara L. Calkins4, and Holden H. Wu1,2
1Radiological Sciences, University of California, Los Angeles, Los Angeles, CA, United States, 2Bioengineering, University of California, Los Angeles, Los Angeles, CA, United States, 3Diagnostic Imaging, St. Jude Children’s Research Hospital, Memphis, TN, United States, 4Pediatrics, University of California, Los Angeles, Los Angeles, CA, United States, 5Siemens Medical Solutions, Salt Lake City, UT, United States

Hepatic stiffness measured by magnetic resonance elastography (MRE) is a biomarker that correlates with histopathological staging of liver fibrosis. Conventional Cartesian gradient-echo MRE requires breath-holding (BH), which may be inconsistent and challenging for children. Free-breathing (FB) MRE based on radial acquisition is a promising solution to this problem. In this study, we investigated the agreement in hepatic stiffness values from BH-MRE and FB-MRE, as well as repeatability, in healthy children and pediatric patients at 3T. Bland-Altman analysis showed a high level of agreement between BH-MRE and FB-MRE, and repeatability analysis showed similar performance for BH-MRE and FB-MRE.

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