Abstract #0091

Time-dependent Diffusion MRI of Pediatric Brain tumor at 3T

Hongxi Zhang¹, Hua Li², Zhipeng Shen¹, Yi Zhang³, and Dan Wu³

¹Children's Hospital, Zhejiang University School of Medicine, Hangzhou, China, ²Nemours AI duPont Hospital for Children, Wilmington, DE, United States, ³Key Laboratory for Biomedical Engineering of Ministry of Education, Department of Biomedical Engineering, College of Biomedical Engineering & Instrument Science, Zhejiang University, Hangzhou, China

Diffusion-time dependent diffusion MRI has shown potential in probing tumor microstructure. This study investigated the feasibility of time-dependent dMRI to map brain tumor microstructure in a pediatric population at 3T. Oscillating and pulsed gradient dMRI was performed to access a series of diffusion times and b-values, and the data were fitted with the IMPULSED model to estimate cell diameter, intracellular fraction, and diffusivity metrics. In a pilot study of 17 pediatric brain tumor patients, all high-grade tumors showed higher intracellular fraction and cellularity than the low-grade ones, while the cell diameter showed differentiation among different types of high-grade tumors.

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.