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Abstract #0091

Time-dependent Diffusion MRI of Pediatric Brain tumor at 3T

Hongxi Zhang1, Hua Li2, Zhipeng Shen1, Yi Zhang3, and Dan Wu3
1Children's Hospital, Zhejiang University School of Medicine, Hangzhou, China, 2Nemours AI duPont Hospital for Children, Wilmington, DE, United States, 3Key Laboratory for Biomedical Engineering of Ministry of Education, Department of Biomedical Engineering, College of Biomedical Engineering & Instrument Science, Zhejiang University, Hangzhou, China

Diffusion-time dependent diffusion MRI has shown potential in probing tumor microstructure. This study investigated the feasibility of time-dependent dMRI to map brain tumor microstructure in a pediatric population at 3T. Oscillating and pulsed gradient dMRI was performed to access a series of diffusion times and b-values, and the data were fitted with the IMPULSED model to estimate cell diameter, intracellular fraction, and diffusivity metrics. In a pilot study of 17 pediatric brain tumor patients, all high-grade tumors showed higher intracellular fraction and cellularity than the low-grade ones, while the cell diameter showed differentiation among different types of high-grade tumors.

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