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Abstract #0092

Optimized MR blood oximetry using multiple T2 maps: validation with MR-guided catheterization in congenital heart disease

Joshua S. Greer1,2, Daniel A. Castellanos1, Yousef Arar1, Surendranath R. Veeram Reddy1, Yin Xi2, Gerald F. Greil1,2,3, Ananth J. Madhuranthakam2,3, and Tarique Hussain1,2
1Pediatrics, UT Southwestern Medical Center, Dallas, TX, United States, 2Radiology, UT Southwestern Medical Center, Dallas, TX, United States, 3Advanced Imaging Research Center, UT Southwestern Medical Center, Dallas, TX, United States

In this study, a recently proposed MRI blood oximetry technique was optimized to improve the accuracy of oxygen saturation measurements. Simulations of the Luz-Meiboom model were performed to optimize the T2-prep refocusing intervals and to guide the selection of the blood pool used for nuisance parameter estimation. Blood oxygen saturation measurements were validated against MR-guided cardiac catheterization under the same anesthetic conditions in patients with congenital heart disease, with the proposed O2 mapping technique demonstrating improved agreement with blood gas analysis. The proposed improvements may allow for future examination of blood pool oxygenation without the need for invasive cardiac catheterization.

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