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Abstract #0093

Myelin water fraction (MWF) mapping using Magnetic Resonance Fingerprinting (MRF) in a cohort of patients from a child neurology unit

Jan W Kurzawski1,2, Matteo Cencini1,3, Laura Biagi1,4, Graziella Donatelli1,5, Rosa Pasquariello4, Roberta Battini3,4, Claudia Dosi3,4, Chiara Ticci3,4, Alessandra Retico2, Guido Buonincontri1,4, and Michela Tosetti1,4
1Imago7, Pisa, Italy, 2INFN, Pisa, Italy, 3University of Pisa, Pisa, Italy, 4IRCCS Stella Maris, Pisa, Italy, 5Neuroradiology, Azienda Ospedaliero-Universitaria Pisana, Pisa, Italy

New advancements in magnetic resonance fingerprinting (MRF) allow more accurate quantification of tissue characteristics and its components using multi-component dictionaries. Recently, a multi-component method for mapping Myelin-Water fraction (MWF) was suggested and validated in healthy children. Here, we studied a cohort with different disorders including hypo- or de- myelinization, Creatine Deficiency Syndrome and brain malformations. We reconstruct MWF maps using tailored dictionaries and estimate fractional myelin values in the splenium of corpus callosum. We observed that myelinization plateaus at around 30 months from birth, while in patients with white matter disorders the process is distorted.

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