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Abstract #0095

Fetal and neonatal whole brain T2* mapping at 3T

Serge Vasylechko1, Emer Hughes2, Joanna Allsop2, Matthew Fox2, Daniel Rueckert1, and Jo Hajnal2
1Biomedical Image Analysis Group, Department of Computing, Imperial College London, London, United Kingdom, 2Centre for the Developing Brain, School of Imaging Sciences and Biomedical Engineering, King's College London, London, United Kingdom

Quantitative T2* mapping in the developing brain is challenging due to inherent motion of fetal and neonatal subjects. This study uses a motion robust framework for acquisition, reconstruction and segmentation of whole brain T2* maps. This is achieved by single-shot multi-echo GRE EPI acquisition, multi-level slice-to-volume registration and gestational-age specific brain atlas segmentation. T2* values are reported for fetal and neonatal subjects at 3T. Findings indicate large variability in T2* within each subject group, non-linear change in T2* between fetal and preterm neonatal period, and significantly higher mean T2* constants than previously reported in adult subjects.

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