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Abstract #0104

Rapid autofocusing of MR-guided focused ultrasound acoustic pressure fields using MR-ARFI with spatially coded emissions

Sumeeth Jonathan1,2, M Anthony Phipps2, Charles F Caskey2, and William A Grissom2
1Biomedical Engineering, Vanderbilt University, Nashville, TN, United States, 2Vanderbilt University Institute of Imaging Science, Vanderbilt University Medical Center, Nashville, TN, United States

Magnetic resonance-guided focused ultrasound (MRgFUS) has many potential neurological applications, but skull-induced aberrations of the acoustic pressure field limit its specificity and safety. MR-acoustic radiation force imaging (MR-ARFI)-based methods have been proposed to refocus the pressure field in situ. However, they take too long for practical in vivo use. We propose a multi-voxel MR-ARFI-based autofocusing method for rapid aberration correction of MRgFUS acoustic pressure fields. We compare our proposed method to the canonical single-voxel MR-ARFI-based refocusing method and demonstrate that as few as two MR-ARFI acquisitions can be used to refocus a programmatically aberrated pressure field.

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