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Abstract #0105

MRI assessment and monitoring of cavitation-based ultrasound therapy (histotripsy) for transcranial brain treatment in vivo

Dinank Gupta1, Ning Lu1, Jonathan Sukovich1, Krisanne Litnas2, Aditya Pandey3, Badih Junior Daou3, Timothy Hall1, Zhen Xu1, Scott Peltier2, and Douglas Noll1
1Biomedical Engineering, University of Michigan, Ann Arbor, MI, United States, 2Functional MRI Laboratory, University of Michigan, Ann Arbor, MI, United States, 3Department of Neurosurgery, University of Michigan, Ann Arbor, MI, United States

Transcranial MR guided cavitation-based Focused Ultrasound (FUS) treatment (histotripsy) is performed in vivo for the first time on a pig brain. Transcranial histotripsy is delivered by an MRI compatible FUS transducer array inside a 3T MRI scanner. Real-time MRI monitoring with 2 second temporal resolution is carried with an intra-voxel incoherent motion (IVIM) pulse sequence synchronized with the FUS array. IVIM images show the histotripsy ablation effect at the intended treatment location in real-time, and the ablation zone was confirmed by post-treatment images. This is the first study to show successful in vivo transcranial histotripsy guided by MRI.

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