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Abstract #0132

Differentiation of Murine Pancreatic Tumours at 7 T with Hyperpolarized 13C-Pyruvate-Lactate MRSI, 18F-FDG PET, and DWI

Geoffrey J. Topping1, Irina Heid2, Moritz Mayer2, Lukas Kritzner2, Florian Englert2, Martin Grashei1, Christian Hundshammer1, Katja Steiger3, Katja Peschke4, Markus Schwaiger1, Maximilian Reichert4, Franz Schilling1, and Rickmer Braren2
1Department of Nuclear Medicine, Klinikum rechts der Isar, Technical University of Munich, Munich, Germany, 2Institute of Radiology, Klinikum rechts der Isar, Technical University of Munich, Munich, Germany, 3Institute of Pathology, Technical University of Munich, Munich, Germany, 4Internal Medicine II, Klinikum rechts der Isar, Technical University of Munich, Munich, Germany

Multimodal imaging for characterization of pancreatic tumour cellularity and metabolism has potential to guide treatment. Murine orthotopically transplanted tumours were imaged with DWI, 13C-pyruvate CSI, and 18F-FDG PET, and endogenous tumours with DWI and CSI. Transplanted epithelial and mesenchymal tumours had similar cellularity, shown by ADC, but different metabolism, with higher mesenchymal AUC ratios and SUV. Compared with other endogenous tumour growth patterns, classical ductal had lower tumour cellularity (higher ADC), while solid had higher and more-variable AUC ratios. The combination of these methods can characterize tumour metabolism, including correcting for tumour cellularity, better than CSI alone.

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