Abstract #0132

Differentiation of Murine Pancreatic Tumours at 7 T with Hyperpolarized 13C-Pyruvate-Lactate MRSI, 18F-FDG PET, and DWI

Geoffrey J. Topping¹, Irina Heid², Moritz Mayer², Lukas Kritzner², Florian Englert², Martin Grashei¹, Christian Hundshammer¹, Katja Steiger³, Katja Peschke⁴, Markus Schwaiger¹, Maximilian Reichert⁴, Franz Schilling¹, and Rickmer Braren²

¹Department of Nuclear Medicine, Klinikum rechts der Isar, Technical University of Munich, Munich, Germany, ²Institute of Radiology, Klinikum rechts der Isar, Technical University of Munich, Munich, Germany, ³Institute of Pathology, Technical University of Munich, Munich, Germany, ⁴Internal Medicine II, Klinikum rechts der Isar, Technical University of Munich, Munich, Germany

Multimodal imaging for characterization of pancreatic tumour cellularity and metabolism has potential to guide treatment. Murine orthotopically transplanted tumours were imaged with DWI, ¹³C-pyruvate CSI, and ¹⁸F-FDG PET, and endogenous tumours with DWI and CSI. Transplanted epithelial and mesenchymal tumours had similar cellularity, shown by ADC, but different metabolism, with higher mesenchymal AUC ratios and SUV. Compared with other endogenous tumour growth patterns, classical ductal had lower tumour cellularity (higher ADC), while solid had higher and more-variable AUC ratios. The combination of these methods can characterize tumour metabolism, including correcting for tumour cellularity, better than CSI alone.

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