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Abstract #0133

Identification of pancreatic intraepithelial neoplasia in the mouse pancreas with MR Microscopy

Carlos Bilreiro1, Rui V. Simões1, Francisca F. Fernandes1, Mireia Castillo-Martin1, Kevin Harkins2, Mark Does2, Celso Matos1, and Noam Shemesh1
1Champalimaud Research, Champalimaud Centre for the Unknown, Lisbon, Portugal, 2Department of Biomedical Engineering, Vanderbilt University, Nashville, TN, United States

Survival in pancreatic cancer resides on an early diagnosis, for which current imaging methods are insufficient. Here, we investigated which MRI contrast can reflect pancreatic pre-neoplastic lesions, particularly, pancreatic intraepithelial neoplasia (PanIN). To this end, we developed an ultrafast DWI-MGE pulse sequence and performed MR microscopy on pancreas extracted from transgenic mice with PanIN lesions (along with controls), and validated our findings using histology. PanIN lesions were clearly detected in the transgenic mice and differentiated from inflammatory changes at b=1000 sec/mm2 and long TE. Our findings are encouraging for future detection of PanIN in vivo.

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