Tumour microstructure can be probed with diffusion-weighted MRI (DW-MRI), but the clinically-adopted apparent diffusion coefficient (ADC) lacks a clear link to microstructure. Aim of this work was to detail the ADC-microstructure relationship using a computational framework. Relying on a sparse representation of simulated DW-MRI data, we estimated diffusivity (D), cell radius (R) and volume fraction (vf) for 27 low and high-grade meningioma patients, which significantly differed in ADC, D and vf. Preliminary results showed the potential of the proposed framework for meningioma grading and proton-therapy response assessment, although extension to richer data and histological validation need to be further addressed.
How to access this content:
For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.
After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.
After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.
Keywords