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Abstract #0138

Parametric maps from the two-tissue compartment model for prostate DCE-MRI: compared with the standard Tofts model in diagnosis of cancer

Xiaobing Fan1, Xueyan Zhou2, Aritrick Chatterjee1, Aytekin Oto1, and Gregory S. Karczmar1
1Radiology, The University of Chicago, Chicago, IL, United States, 2Harbin University, Harbin, China

We compared standard Tofts model with a two-tissue compartment model (2TCM) of dynamic contrast enhanced (DCE) MRI for diagnosis of prostate cancer. The 2TCM has one slow and one fast exchanging compartment. The standard Tofts model parameters (Ktrans and kep) were compared with the 2TCM parameters (Kitrans and kiep, i=1,2). There was a strong correlation between Ktrans and K1trans for cancer, but weak correlation between kep and k1ep. This demonstrated that the Tofts model often does not fit contrast agent concentration curves accurately, and the 2TCM can provide new diagnostic information with fewer false positives in diagnosis of prostate cancer.

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