Abstract #0138

Parametric maps from the two-tissue compartment model for prostate DCE-MRI: compared with the standard Tofts model in diagnosis of cancer

Xiaobing Fan¹, Xueyan Zhou², Aritrick Chatterjee¹, Aytekin Oto¹, and Gregory S. Karczmar¹

¹Radiology, The University of Chicago, Chicago, IL, United States, ²Harbin University, Harbin, China

We compared standard Tofts model with a two-tissue compartment model (2TCM) of dynamic contrast enhanced (DCE) MRI for diagnosis of prostate cancer. The 2TCM has one slow and one fast exchanging compartment. The standard Tofts model parameters (K^trans and k_ep) were compared with the 2TCM parameters (K_i^trans and kⁱ_ep, i=1,2). There was a strong correlation between K^trans and K₁^trans for cancer, but weak correlation between k_ep and k¹_ep. This demonstrated that the Tofts model often does not fit contrast agent concentration curves accurately, and the 2TCM can provide new diagnostic information with fewer false positives in diagnosis of prostate cancer.

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