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Abstract #0139

3D multi-shot diffusion imaging of the prostate with inter-shot correction and dictionary-based ADC matching

Elisa Roccia1, Radhouene Neji1,2, Thomas Benkert3, Berthold Kiefer3, Vicky Goh4, and Isabel Dregely1
1Biomedical Engineering Department, School of Biomedical Engineering and Imaging Sciences, King's College London, London, United Kingdom, 2Siemens Healthcare Limited, Frimley, United Kingdom, 3Siemens Healthcare GmbH, Erlangen, Germany, 4Cancer Imaging Department, School of Biomedical Engineering and Imaging Sciences, King's College London, London, United Kingdom

Diffusion imaging is a key contrast in assessing prostate cancer. However, current single-shot EPI-based techniques are often distorted and fundamentally limited in resolution. The aim of this study is to develop multi-shot diffusion-prepared gradient echo imaging to obtain accurate 3D ADC maps in the prostate. We developed a 3D Cartesian centric trajectory with self-navigation, and a shot rejection approach to correct for inter-shot magnitude errors. We used a custom dictionary of acquisition specific signal evolutions to estimate ADC. We have shown in simulations and in vivo that accurate ADC values could be recovered.

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