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Abstract #0140

Investigation of breast cancer microstructure and microvasculature from time-dependent DWI and CEST in correlation with histology

Yuko Someya1, Mami Iima1,2, Hirohiko Imai3, Akihiko Yoshizawa4, Yuji Nakamoto1, Masako Kataoka1, Hiroyoshi Isoda1, and Kaori Togashi1
1Diagnostic Imaging and Nuclear Medicine, Kyoto University Graduate School of Medicine, Kyoto, Japan, 2Clinical Innovative Medicine, Institute for Advancement of Clinical and Translational Science, Kyoto University Hospital, Kyoto, Japan, 3Kyoto University Graduate School of Informatics, Kyoto, Japan, 4Diagnostic Pathology, Kyoto University Graduate School of Medicine, Kyoto, Japan

The association of time-dependent DWI (shifted ADC [sADC], IVIM, and non-Gaussian DWI) at different diffusion times and CEST (MTRasym, APT signal intensity) parameters was investigated with histological biomarkers in a breast cancer xenograft model. ADC values decreased with increased diffusion times. sADC values at a diffusion time=5ms had significant negative correlation with Ki-67 (r=−0.63, P<0.05). MTRasym had a significant positive correlation with Ki-67 positive area (r=0.73, P<0.05). Significant association was found between fIVIM and microvessel density (r=0.80, P<0.01). These results indicate their utility for investigating microstructure and microcirculation of breast cancers without using contrast agents.

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