Abstract #0140

Investigation of breast cancer microstructure and microvasculature from time-dependent DWI and CEST in correlation with histology

Yuko Someya¹, Mami Iima^1,2, Hirohiko Imai³, Akihiko Yoshizawa⁴, Yuji Nakamoto¹, Masako Kataoka¹, Hiroyoshi Isoda¹, and Kaori Togashi¹

¹Diagnostic Imaging and Nuclear Medicine, Kyoto University Graduate School of Medicine, Kyoto, Japan, ²Clinical Innovative Medicine, Institute for Advancement of Clinical and Translational Science, Kyoto University Hospital, Kyoto, Japan, ³Kyoto University Graduate School of Informatics, Kyoto, Japan, ⁴Diagnostic Pathology, Kyoto University Graduate School of Medicine, Kyoto, Japan

The association of time-dependent DWI (shifted ADC [sADC], IVIM, and non-Gaussian DWI) at different diffusion times and CEST (MTR_asym, APT signal intensity) parameters was investigated with histological biomarkers in a breast cancer xenograft model. ADC values decreased with increased diffusion times. sADC values at a diffusion time=5ms had significant negative correlation with Ki-67 (r=−0.63, P<0.05). MTR_asym had a significant positive correlation with Ki-67 positive area (r=0.73, P<0.05). Significant association was found between f_IVIM and microvessel density (r=0.80, P<0.01). These results indicate their utility for investigating microstructure and microcirculation of breast cancers without using contrast agents.

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