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Abstract #0141

Perfusion MRI related to survival, treatment response and sex differences in rectal cancer

Kine Mari Bakke1,2, Sebastian Meltzer1, Endre Grøvik3, Anne Negård4,5, Stein Harald Holmedal4, Kjell-Inge Gjesdal4, Atle Bjørnerud2,3, Anne Hansen Ree1,5, and Kathrine Røe Redalen6
1Department of Oncology, Akershus University Hospital, Lørenskog, Norway, 2Department of Physics, University of Oslo, Oslo, Norway, 3Department of Diagnostic Physics, Division of Radiology and Nuclear Medicine, Oslo University Hospital, Oslo, Norway, 4Department of Radiology, Akershus University Hospital, Lørenskog, Norway, 5Institute of Clinical Medicine, University of Oslo, Oslo, Norway, 6Department of Physics, Norwegian University of Science and Technology, Trondheim, Norway

Three different MRI methods for obtaining perfusion related parameters were compared and evaluated as biomarkers in a study of 94 rectal cancer patients. The methods were dynamic contrast enhanced (DCE) MRI and dynamic susceptibility contrast (DSC) MRI analysed from a multi-echo dynamic EPI sequence, as well as intravoxel incoherent motion (IVIM) MRI analysed from a diffusion weighted sequence with 7 b-values. Tumour blood flow from DSC MRI was correlated to D* from IVIM MRI as well as Ktrans and vp from DCE MRI. Blood flow was also related to progression free survival, overall survival, treatment response and sex differences.

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