Abstract #0141

Perfusion MRI related to survival, treatment response and sex differences in rectal cancer

Kine Mari Bakke^1,2, Sebastian Meltzer¹, Endre Grøvik³, Anne Negård^4,5, Stein Harald Holmedal⁴, Kjell-Inge Gjesdal⁴, Atle Bjørnerud^2,3, Anne Hansen Ree^1,5, and Kathrine Røe Redalen⁶

¹Department of Oncology, Akershus University Hospital, Lørenskog, Norway, ²Department of Physics, University of Oslo, Oslo, Norway, ³Department of Diagnostic Physics, Division of Radiology and Nuclear Medicine, Oslo University Hospital, Oslo, Norway, ⁴Department of Radiology, Akershus University Hospital, Lørenskog, Norway, ⁵Institute of Clinical Medicine, University of Oslo, Oslo, Norway, ⁶Department of Physics, Norwegian University of Science and Technology, Trondheim, Norway

Three different MRI methods for obtaining perfusion related parameters were compared and evaluated as biomarkers in a study of 94 rectal cancer patients. The methods were dynamic contrast enhanced (DCE) MRI and dynamic susceptibility contrast (DSC) MRI analysed from a multi-echo dynamic EPI sequence, as well as intravoxel incoherent motion (IVIM) MRI analysed from a diffusion weighted sequence with 7 b-values. Tumour blood flow from DSC MRI was correlated to D^* from IVIM MRI as well as K^trans and v_p from DCE MRI. Blood flow was also related to progression free survival, overall survival, treatment response and sex differences.

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