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Abstract #0148

Low dose brain irradiation leads to delayed neuro-inflammation 

Dina Sikpa1, Jérémie P. Fouquet1, Luc Tremblay1, Réjean Lebel1, Benoit Paquette1, and Martin Lepage1
1Université de Sherbrooke, Sherbrooke, QC, Canada

We studied the late radiation effect of a low radiation dose on the healthy mouse brain using MRI and histology. MRI enables the visualisation of early inflammation and late radiation necrosis. Histological analysis confirmed tissue damage and revealed that cellular (astrocytes, microglia) and molecular activation (ICAM-1, VCAM-1) as a result of neuro-inflammation precedes the formation of the necrotic core.

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