Brain metastases are treated with single fraction stereotactic radiosurgery (sf-SRS) or hypofractionated radiation therapy (HFTR). CEST was previously shown to identify responders to sf-SRS within one-week post-treatment. This study investigated the differences in CEST and MT properties of brain metastases treated with sf-SRS and 5 fraction HFRT (5f-HFRT) one week after treatment. We observed statistically significantly larger reduction in CEST properties of tumours treated with sf-SRS compared to those treated with 5f-HFRT. However, changes in MT properties of the two cohort were similar. Such differences should be considered when evaluating response of brain metastases to radiotherapy using CEST and MT.