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Abstract #0147

Impact of Single Fraction Stereotactic Radiosurgery vs. Hypofractionated Radiation Therapy on CEST and MT Parameters of Brain Metastases

Hatef Mehrabian1, Wilfred W Lam1, Hany Soliman1,2,3, Sten Myrehaug2,3, Arjun Sahgal1,2,3, and Greg J Stanisz1,4
1Physical Sciences, Sunnybrook Research Institute, Toronto, ON, Canada, 2Radiation Oncology, Sunnybrook Health Sciences Centre, Toronto, ON, Canada, 3Radiation Oncology, University of Toronto, Toronto, ON, Canada, 4Medical Biophysics, University of Toronto, Toronto, ON, Canada

Brain metastases are treated with single fraction stereotactic radiosurgery (sf-SRS) or hypofractionated radiation therapy (HFTR). CEST was previously shown to identify responders to sf-SRS within one-week post-treatment. This study investigated the differences in CEST and MT properties of brain metastases treated with sf-SRS and 5 fraction HFRT (5f-HFRT) one week after treatment. We observed statistically significantly larger reduction in CEST properties of tumours treated with sf-SRS compared to those treated with 5f-HFRT. However, changes in MT properties of the two cohort were similar. Such differences should be considered when evaluating response of brain metastases to radiotherapy using CEST and MT.

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