Abstract #0156

7 Tesla Diffusion Tensor Imaging and Quantitative Susceptibility Mapping of Huntington’s Disease

Paul Rowley^1,2, Melanie Morrison, PhD¹, Yicheng Chen¹, Angela Jakary¹, Michael Geschwind, MD, PhD³, Alexandra Nelson, MD, PhD³, Duan Xu, PhD¹, Christopher Hess, MD, PhD¹, and Janine Lupo, PhD¹

¹Radiology & Biomedical Imaging, University of California, San Francisco, San Francisco, CA, United States, ²University of Wisconsin School of Medicine and Public Health, Madison, WI, United States, ³Neurology, University of California, San Francisco, San Francisco, CA, United States

Ultra-high-field 7 Tesla (7T) MRI was acquired to examine and compare white matter microstructure and quantitative susceptibility in patients with premanifest (PM) and early manifest (EM) Huntington’s disease (HD) and age-matched healthy control (HC) subjects. Tract-averaged and along-tract fractional anisotropy (FA) and susceptibility (PPM) were calculated to determine the spatial spread of disease along motor tracks originating from the striatum and ending in the cortex. HC and PM patients demonstrated different areas of significantly increased susceptibility compared to EM at the tract-averaged level as well as significant focal along-tract variations in FA and susceptibility which were undetected by tract-averaged analysis.

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