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Abstract #0155

Morphology Enabled Quantitative Conductivity–Susceptibility Mapping with B1 and B0 Estimation from Complex Multi-echo Gradient Echo Signal

Motofumi Fushimi1,2, Thanh Nguyen2, and Yi Wang2,3
1Graduate School of Information Science and Technology, The University of Tokyo, Tokyo, Japan, 2Radiology, Weill Cornell Medical College, New York, NY, United States, 3Biomedical Engineering, Cornell University, Ithaca, NY, United States

We propose a simultaneous conductivity and susceptibility reconstruction method by estimating B1 phase and B0 distributions from a multi-echo gradient echo (mGRE) signal. B1 phase and B0 maps are simultaneously determined by applying nonlinear least squares method on the complex signal equation of the mGRE signal. The poor conditioned inversion of field (B1/B0) to source (conductivity/susceptibility) is regularized using anatomical information. This morphology enabled quantitative conductivity and susceptibility mapping (QCSM) was performed on healthy subjects and patients with brain tumors. Our preliminary in-vivo experiments demonstrated that the proposed QCSM method can reconstruct conductivity and susceptibility from a single mGRE acquisition.

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