Abstract #0164

Variation of In Vivo Anisotropic MRE Metrics in Corpus Callosum: Effect of Aging

Nicolas R Gallo¹, Stacey M Cahoon¹, Aaron T Anderson², Noel M Naughton³, Assimina A Pelegri⁴, and John G Georgiadis¹

¹Biomedical Engineering, Illinois Institute of Technology, Chicago, IL, United States, ²Beckman Institute, Urbana, IL, United States, ³Department of Mechanical Science and Engineering, University of Illinois at Urbana-Champaign, Urbana, IL, United States, ⁴Department of Mechanical and Aerospace Engineering, Rutgers University, New Brunswick, NJ, United States

Healthy aging involves local variations in viscoelastic shear properties of the brain. We employ high-resolution, multi-excitation MRE and a novel anisotropic inversion scheme (iTI) to extract local shear anisotropic moduli in vivo. The ratio of transverse to axial moduli, a new MRE metric, remains greater than 1 along the splenium, body and genu regions of the corpus callosum for both young and old subjects. This metric peaks in the body region and decreases with age throughout the corpus callosum.

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