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Abstract #0163

Model-based heterogenous transverse isotropic MR elastography inversion for brain tissue with aligned fiber tracts

Matthew Mcgarry1, Elijah Van Houten2, Damian Sowinski1, Philip Bayly3, Daniel Smith4, Curtis Johnson4, John Weaver1,5, and Keith Paulsen1,5
1Dartmouth College, Hanover, NH, United States, 2Université de Sherbrooke, Sherbrooke, QC, Canada, 3Washington University in St Louis, St Louis, MO, United States, 4University of Delaware, Newark, DE, United States, 5Dartmouth-Hitchcock Medical Center, Lebanon, NH, United States

An implementation of a transverse isotropic model with fiber directions defined by DTI was added to our finite element model-based nonlinear inversion MRE platform. The algorithm can recover accurate images of complex valued shear modulus, shear anisotropy, and tensile anisotropy from a realistic brain simulation. In vivo application to multi-excitation brain MRE data produced promising results, maintaining high quality images for the base shear modulus and damping ratio, while recovering additional images of anisotropy which may be useful for characterizing diseases affecting white matter tracts or muscle.

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