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Abstract #0173

A Change in Membrane Potential Induces Measurable Changes in Relaxation Times

Kyeongseon Min1, Tan Toi Phan2,3, Sungkwon Chung4, Jongho Lee1, Seung-Kyun Lee2,3, and Jang-Yeon Park2,3
1Laboratory for Imaging Science and Technology, Department of Electrical and Computer Engineering, Seoul National University, Seoul, Korea, Republic of, 2Department of Biomedical Engineering, Sungkyunkwan University, Suwon, Korea, Republic of, 3Center for Neuroscience Imaging Research, Institute for Basic Science, Suwon, Korea, Republic of, 4Department of Physiology, Samsung Biomedical Research Institute, Sungkyunkwan University School of Medicine, Suwon, Korea, Republic of

In this study, the effects of membrane potential on T1 and T2 were examined using Jurkat T lymphocytes. We applied tetraethylammonium ion (TEA) to depolarize Jurkat cell membrane potential. Significant changes in T1 and T2, which were measured to be -10.39 ms/mM and 0.920 ms/mM, respectively, were observed. One potential explanation for the changes of T1 and T2 is the depolarization of membrane potential, while the underlying mechanism needs to be explored. Further studies are expected to utilize the membrane potential as a new contrast mechanism for MRI.

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