Kyeongseon Min1, Tan Toi Phan2,3, Sungkwon Chung4, Jongho Lee1, Seung-Kyun Lee2,3, and Jang-Yeon Park2,3
1Laboratory for Imaging Science and Technology, Department of Electrical and Computer Engineering, Seoul National University, Seoul, Korea, Republic of, 2Department of Biomedical Engineering, Sungkyunkwan University, Suwon, Korea, Republic of, 3Center for Neuroscience Imaging Research, Institute for Basic Science, Suwon, Korea, Republic of, 4Department of Physiology, Samsung Biomedical Research Institute, Sungkyunkwan University School of Medicine, Suwon, Korea, Republic of
study, the effects of membrane potential on T1 and T2 were examined using Jurkat T lymphocytes. We applied tetraethylammonium
ion (TEA) to depolarize
Jurkat cell membrane potential. Significant changes in T1 and T2, which were measured to be -10.39 ms/mM and 0.920 ms/mM, respectively, were observed.
One potential explanation for the changes of T1 and T2 is
the depolarization of membrane potential, while the underlying mechanism needs
to be explored. Further studies are expected to utilize the membrane potential
as a new contrast mechanism for MRI.