Abstract #0173

A Change in Membrane Potential Induces Measurable Changes in Relaxation Times

Kyeongseon Min¹, Tan Toi Phan^2,3, Sungkwon Chung⁴, Jongho Lee¹, Seung-Kyun Lee^2,3, and Jang-Yeon Park^2,3

¹Laboratory for Imaging Science and Technology, Department of Electrical and Computer Engineering, Seoul National University, Seoul, Korea, Republic of, ²Department of Biomedical Engineering, Sungkyunkwan University, Suwon, Korea, Republic of, ³Center for Neuroscience Imaging Research, Institute for Basic Science, Suwon, Korea, Republic of, ⁴Department of Physiology, Samsung Biomedical Research Institute, Sungkyunkwan University School of Medicine, Suwon, Korea, Republic of

In this study, the effects of membrane potential on T₁ and T₂ were examined using Jurkat T lymphocytes. We applied tetraethylammonium ion (TEA) to depolarize Jurkat cell membrane potential. Significant changes in T₁ and T₂, which were measured to be -10.39 ms/mM and 0.920 ms/mM, respectively, were observed. One potential explanation for the changes of T₁ and T₂ is the depolarization of membrane potential, while the underlying mechanism needs to be explored. Further studies are expected to utilize the membrane potential as a new contrast mechanism for MRI.

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