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Abstract #0174

Quantifying the Transchelation of Gd3+ Ions from Linear and Macrocyclic GBCA to Glycosaminoglycans using MR Relaxometry

Patrick Schuenke1, Patrick Werner1,2, Matthias Taupitz3, and Leif Schröder1
1Leibniz-Forschungsinstitut fuer Molekulare Pharmakologie (FMP), Berlin, Germany, 2BIOQIC, Charité Berlin, Berlin, Germany, 3Department of Radiology, Charité Berlin, Berlin, Germany

In this study, we quantified the dissociation of GBCAs at different ZnCl2 concentrations and the subsequent chelation of Gd3+ to glycosaminoglycans (GAGs) like heparin. We showed that the relaxivity of the resulting Gd-GAG complexes is about seven times higher compared to that of GBCAs. Under physiological conditions, we further showed that ~20% of the Gd3+-ions transchelated from linear GBCAs to heparin and that these are accountable for more than 50% of the observed relaxation rate. Therefore, Gd-GAG complexes should be considered as the Gd-containing macromolecular substances with high relaxivity that are needed to explain the observed long-term enhancements in vivo.

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