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Abstract #0186

Perivascular space imaging across the lifespan

Kirsten M Lynch1, Giuseppe Barisano1, Arthur W Toga1, and Farshid Sepehrband1
1Mark and Mary Stevens Institute for Neuroimaging and Informatics, University of Southern California, Los Angeles, CA, United States

The perivascular space (PVS) is a major component of the glymphatic system and it promotes functional brain clearance. PVS enlargement has been observed in neurological disorders and is considered a biomarker for vascular pathology, however its role in normative development is not well understood. Using a novel technique to segment PVS, we sought to quantify age-related changes in PVS across the lifespan in a large cross-sectional cohort of cognitively normal individuals. We found age was significantly and positively associated with PVS throughout the brain and these results provide a first step towards understanding the typical evolution of brain clearance mechanisms.

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