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Abstract #0187

Increased Blood-Brain Interface Water Permeability in the Ageing Brain detected using non-invasive Multiple Echo Time ASL MRI

Yolanda Ohene1, Ian F. Harrison1, David L. Thomas2,3,4, Mark F. Lythgoe 1, and Jack A. Wells 1
1Centre for Advanced Biomedical Imaging, UCL, London, United Kingdom, 2Neuroradiological Academic Unit, UCL Queen Square Institute of Neurology, UCL, London, United Kingdom, 3Dementia Research Centre, UCL Queen Square Institute of Neurology, UCL, London, United Kingdom, 4Wellcome Centre for Humans Neuroimaging, UCL Queen Square Institute of Neurology, UCL, London, United Kingdom

Multi-TE ASL technique detects a significant increase (32%) in blood-brain interface (BBI) permeability in the ageing brain. The change in BBI water permeability is associated with a marked increase (1.9 ± 0.4 fold) in expression of PDGFRβ, an index of pericyte coverage, and changes to aquaporin water channels and their anchoring proteins in the ageing brain. This technique is a promising non-invasive tool to measure age-related changes to the BBI, that may play a mechanistic role in the pathogenesis of neurodegenerative conditions.

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