In investigating the problem of CEST correction methods for low saturation B1, we observed differences in the behavior of the CEST asymmetry signal as a function of age. We believe this incidental observation to be a manifestation of the low saturation power induced NOE reported in other literature. In this case, we hypothesize that the physiological phenomenon underlying the pattern we observe is a decrease in myelin or other lipids in the aging brain. Our T1 maps corroborate literature collected at lower field strength that T1 values increase with age; however, this appears to be an independent, if related, phenomenon.
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