Abstract #0191

Altered lactate dynamics with age in human brain during sleep

Manoj K. Sammi¹, Katherine Powers¹, Chloe Robinson¹, Selda Yildiz^1,2, Miranda Lim^2,3,4,5,6, Jeffrey J Iliff^7,8,9,10,11, and William D Rooney^1,2,5,9

¹Advanced Imaging Research Center, Oregon Health & Science University, Portland, OR, United States, ²Department of Neurology, Oregon Health & Science University, Portland, OR, United States, ³VA Portland Health Care System, Portland, OR, United States, ⁴Department of Medicine, Division of Pulmonary and Critical Care Medicine, Oregon Health & Science University, Portland, OR, United States, ⁵Department of Behavioral Neuroscience, Oregon Health & Science University, Portland, OR, United States, ⁶Oregon Institute of Occupational Health Sciences, Oregon Health & Science University, Portland, OR, United States, ⁷Department of Neurology, University of Washington, Seattle, WA, United States, ⁸Department of Anesthesiology and Perioperative Medicine, Oregon Health & Science University, Portland, OR, United States, ⁹Knight Cardiovascular Institute, Oregon Health & Science University, Portland, OR, United States, ¹⁰VISN 20 Mental Illness Research, Education and Clinical Center (MIRECC), VA Puget Sound Health Care System, Seattle, WA, United States, ¹¹Department of Psychiatry and Behavioral Sciences, University of Washington, Seattle, WA, United States

Lactate dynamics during sleep-awake cycle in human brain are studied non-invasively using single voxel diffusion weighted magnetic resonance spectroscopy (MRS) technique with simultaneous polysomnography (PSG) recordings to characterize sleep stages. Awake lactate apparent diffusion coefficients (ADC) values are large compared to other brain metabolites and may support active transport - Astrocyte-Neuron Lactate Shuttle (ANLS) mechanism. Lactate ADC are reduced in deep sleep stage in young subjects but are unchanged in older subjects. These results may reflect different interstitial fluid exchange activity or changed metabolic state with aging and require further research.

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.