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Abstract #0192

Age differences in hippocampal glutamate modulation during associative encoding: A proton functional magnetic resonance spectroscopy study

Chaitali Anand1, Dalal Khatib1, Cheryl Dahle2, Naftali Raz2, and Jeffrey Stanley1
1Psychiatry and Behavioral Neuroscience, Wayne State University, Detroit, MI, United States, 2Psychology, Wayne State University, Institute of Gerontology, Detroit, MI, United States

Memory declines early in normal aging, worsening in dementia. Glutamatergic neurons, abundant in the hippocampus, play a pivotal role in synaptic plasticity underlying formation of associations. We have previously demonstrated with 1H fMRS, significant modulation of hippocampal glutamate during encoding of object-location associations. We observed that the timing of modulation differentiated proficiency in acquiring the associations. Because age-related hippocampal atrophy may be accompanied by glutamatergic dysfunction, age-differences in task-related levels of hippocampal glutamate may provide a marker of age-related memory deficits. Here, we identified age-differences in hippocampal glutamate modulation during associative memory encoding, which may underlie age-related associative memory deficits.

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