Abstract #0193

Reliable High-Resolution MR Elastography Protocol to Assess Hippocampal Subfield Viscoelasticity in Aging

Peyton L Delgorio¹, Lucy V Hiscox¹, Ryan T Pohlig¹, Faria Sanjana¹, Ana M Daugherty², Hillary Schwarb³, Christopher R Martens¹, Matthew DJ McGarry⁴, and Curtis L Johnson¹

¹University of Delaware, Newark, DE, United States, ²Wayne State University, Detroit, MI, United States, ³University of Illinois at Urbana-Champaign, Urbana, IL, United States, ⁴Dartmouth College, Hanover, NH, United States

The goal of this study is to generate the first high-resolution magnetic resonance elastography (MRE) protocol specifically for characterizing viscoelasticity of the hippocampal subfields (HCsf) and analyzing the effects of age on HCsf properties. We demonstrated that the protocol can sensitively and reliably differentiate between HCsf regions. We find that each HCsf decreases in stiffness and increases in damping ratio with age, and that HCsf exhibit differential relationships with age. This protocol shows promise for investigating the HCsf in health and disease.

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