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Abstract #0194

Effects of Arterial Stiffness on Cerebral White Matter Integrity in the Elderly

Koji Kamagata1, Christina Andica1, Kazunori Shimada2, Hideyoshi Kaga3, Yuki Someya3,4, Yuya Saito1,5, Toshiaki Akashi1, Akihiko Wada1, Yoshifumi Tamura3,4, Ryuzo Kawamori3,4, Hirotaka Watada3, Hiroyuki Daida2, and Shigeki Aoki1
1Department of Radiology, Juntendo University, Tokyo, Japan, 2Department of Cardiovascular Medicine, Juntendo University, Tokyo, Japan, 3Department of Metabolism & Endocrinology, Juntendo University, Tokyo, Japan, 4Sportology Center, Juntendo University, Tokyo, Japan, 5Department of Radiological Sciences, Tokyo Metropolitan University, Tokyo, Japan

Arterial stiffness has been shown to be associated with structural and functional abnormalities in the brain; however, white matter pathology related to arterial stiffness is poorly understood. In this study, we used white matter (WM) sensitive techniques (diffusion tensor imaging, neurite orientation dispersion and density imaging, free-water imaging, and magnetization transfer-saturation imaging) to better understand the impact of arterial stiffness on the WM microstructure in healthy elderly individuals. Our results suggest that arterial stiffness largely affects the content of cerebral myelin, as reflected by the myelin volume fraction.

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