Abstract #0206

Association of ApoE gene polymorphism and caudate functional connectivity in mild cognitive impairment of Parkinson’s disease

Song'an Shang¹, Weiqiang Dou², Hongying Zhang³, Jing Ye³, and Jingtao Wu³

¹Department of Radiology, Nanjing First Hospital, Nanjing Medical University, Nanjing, China, ²GE Healthcare, MR Research China, Beijing, China, ³Northern Jiangsu People’s Hospital, Yangzhou, China

In this study, we aimed to investigate the association of Apolipoprotein E (ApoE) gene polymorphism and caudate functional connectivity in mild cognitive impairment of Parkinson’s disease (PD-MCI), using resting-state functional magnetic resonance imaging (rs-fMRI) and genotyping. Our findings revealed that gene-brain-behavior associations involve alterations of caudate activity with posterior cortical, thereby provide potential imaging-based markers that contribute to the early diagnosis and monitoring of PD-MCI.

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