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Abstract #0206

Association of ApoE gene polymorphism and caudate functional connectivity in mild cognitive impairment of Parkinson’s disease

Song'an Shang1, Weiqiang Dou2, Hongying Zhang3, Jing Ye3, and Jingtao Wu3
1Department of Radiology, Nanjing First Hospital, Nanjing Medical University, Nanjing, China, 2GE Healthcare, MR Research China, Beijing, China, 3Northern Jiangsu People’s Hospital, Yangzhou, China

In this study, we aimed to investigate the association of Apolipoprotein E (ApoE) gene polymorphism and caudate functional connectivity in mild cognitive impairment of Parkinson’s disease (PD-MCI), using resting-state functional magnetic resonance imaging (rs-fMRI) and genotyping. Our findings revealed that gene-brain-behavior associations involve alterations of caudate activity with posterior cortical, thereby provide potential imaging-based markers that contribute to the early diagnosis and monitoring of PD-MCI.

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