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Abstract #0207

Dopaminergic premotor and motor pathways are dominant in the progression of motor disability in Parkinson’s disease

Yao Chia Shih1, Septian Hartono2,3, Amanda Choo2, Celeste Chen2, Isabel Chew1, Zheyu Xu2,3, Louis Tan2,3, ChingYu Cheng3,4, Eng King Tan2,3, and Ling Ling Chan1,3
1Department of Diagnostic Radiology, Singapore General Hospital, Singapore, Singapore, 2Department of Neurology, National Neuroscience Institute – SGH Campus, Singapore, Singapore, 3Duke-NUS Medical School, Singapore, Singapore, 4Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore

White matter microstructural changes in relation to the neurotransmitter systems in Parkinson’s disease (PD) progression remains unclear. We used diffusion spectrum imaging and local connectome fingerprint analysis to investigate microstructural integrity of the the premotor and motor pathways in associations with various neurotransmitter systems in the brainstem, and disease duration and severity of motor-related symptoms. We found greater microstructural changes in the dopaminergic pathways in association with motor progression than for the other neurochemical pathways. Patients with longer disease duration or more severe motor dysfunctions showed increased anisotropic water diffusion in these pathways, suggesting a compensatory effect of axonal sprouting.

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