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Abstract #0208

QUANTITATIVE SUSCEPTIBILITY MAPPING AS A DIAGNOSTIC TOOL TO DISTINGUISH TREMOR DOMINANT PD FROM ESSENTIAL TREMOR.

Shumyla Jabeen1, Jitender Saini1, Jaladhar Neelavalli2, Narayankrishna Rolla2, Shweta Prasad3, and Ravi Yadav4
1Neuroimaging and Interventional Radiology, National Institute of Mental Health and Neurosciences, Bangalore, India, 2Philips India, Bangalore, India, 3Clinical neurosciences, National Institute of Mental Health and Neurosciences, Bangalore, India, 4Neurology, National Institute of Mental Health and Neurosciences, bangalore, India

Tremor dominant PD and ET often pose a diagnostic difficulty in view of overlapping clinical features. We aimed at distinguishing the two using the novel technique of QSM to measure iron deposition in various gray matter nuclei including the substantia nigra pars compacta(SNPc). A statistically significant difference was seen in the QSM values of the SNPc, SNPr and caudate nucleus. ROC curve analysis showed a sensitivity and specificity of 90 and 87.5% respectively using a cut off value of 12 ppb for the SNPc. Thus, QSM is a potentially useful problem solving technique for distinguishing tremor dominant PD from ET.

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