Abstract #0210

Effects of Levodopa Therapy on Cerebral Arteries and Brain Tissue Perfusion in Parkinson’s Disease Patients

Yuhui Xiong^1,2, Lanxin Ji¹, Le He¹, Li Chen³, Xue Zhang¹, Zhensen Chen³, Xuesong Li⁴, Huilin Zhao³, Manabu Shirakawa³, Chun Yuan³, Yu Ma⁵, and Hua Guo¹

¹Center for Biomedical Imaging Research, Department of Biomedical Engineering, School of Medicine, Tsinghua University, Beijing, China, ²Neusoft Medical Systems Co., Ltd., Shanghai, China, ³Vascular Imaging Laboratory, Department of Radiology, University of Washington, Seattle, WA, United States, ⁴School of Computer Science and Technology, Beijing Institute of Technology, Beijing, China, ⁵Tsinghua University Yuquan Hospital, Beijing, China

Parkinson’s Disease (PD) has shown to be associated with cerebrovascular abnormalities, but its non-dopaminergic pathological mechanism is less studied. This study investigated the regulatory effect of levodopa, the most-commonly used therapy for PD, on cerebral arteries and blood flow. 57 PD patients and 17 age-matched healthy controls were scanned for artery morphologic and cerebral perfusion imaging at baseline, then the patients were re-scanned 50 minutes after taking levodopa. Results indicated that levodopa elevated blood perfusion level of PD brains to normal levels and dilated proximal arteries. Plus, blood perfusion showed related to motor syndrome scale post-levodopa.

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