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Abstract #0210

Effects of Levodopa Therapy on Cerebral Arteries and Brain Tissue Perfusion in Parkinson’s Disease Patients

Yuhui Xiong1,2, Lanxin Ji1, Le He1, Li Chen3, Xue Zhang1, Zhensen Chen3, Xuesong Li4, Huilin Zhao3, Manabu Shirakawa3, Chun Yuan3, Yu Ma5, and Hua Guo1
1Center for Biomedical Imaging Research, Department of Biomedical Engineering, School of Medicine, Tsinghua University, Beijing, China, 2Neusoft Medical Systems Co., Ltd., Shanghai, China, 3Vascular Imaging Laboratory, Department of Radiology, University of Washington, Seattle, WA, United States, 4School of Computer Science and Technology, Beijing Institute of Technology, Beijing, China, 5Tsinghua University Yuquan Hospital, Beijing, China

Parkinson’s Disease (PD) has shown to be associated with cerebrovascular abnormalities, but its non-dopaminergic pathological mechanism is less studied. This study investigated the regulatory effect of levodopa, the most-commonly used therapy for PD, on cerebral arteries and blood flow. 57 PD patients and 17 age-matched healthy controls were scanned for artery morphologic and cerebral perfusion imaging at baseline, then the patients were re-scanned 50 minutes after taking levodopa. Results indicated that levodopa elevated blood perfusion level of PD brains to normal levels and dilated proximal arteries. Plus, blood perfusion showed related to motor syndrome scale post-levodopa.

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