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Abstract #0211

Spatio-temporal alterations in functional connectivity, microstructure and cerebral glucose metabolism in a rat model of sporadic Alzheimer’s

Yujian Diao1, Catarina Tristão Pereira2, Carole Poitry-Yamate1, Ting Yin1, Analina Raquel da Silva1, Rolf Gruetter1, and Ileana Ozana Jelescu1
1Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland, 2Faculdade de Ciências da Universidade de Lisboa, Lisbon, Portugal

Impaired brain glucose consumption is a possible trigger of Alzheimer’s disease (AD). Animal models can help characterize each contributor to the cascade independently. Here we report a comprehensive longitudinal study of functional connectivity, white matter microstructure and brain glucose metabolism using resting-state fMRI, diffusion MRI and FDG-PET in the intracerebroventricular-streptozotocin rat model of AD. Our study highlights the dynamics of how brain insulin resistance affects brain structure and function, and identifies potent MRI-derived biomarkers to track neurodegeneration in human AD and diabetic populations.

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