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Abstract #0212

Dynamic glucose enhanced (DGE) MRI at 3T detects alterations in glucose uptake and clearance in young and old Alzheimer’s mice

Jianpan Huang1, Xiongqi Han1, Celia M. Dong2, Gerald W. Y. Cheng3, Kai-Hei Tse3, Lin Chen4,5, Joseph H. C. Lai1, Ed X. Wu2, Peter C. M. van Zijl4,5, Jiadi Xu4,5, and Kannie W. Y. Chan1,4
1Department of Biomedical Engineering, City University of Hong Kong, Hong Kong, China, 2Department of Electrical and Electronic Engineering, The University of Hong Kong, Hong Kong, China, 3Department of Health Technology and Informatics, The Hong Kong Polytechnic University, Hong Kong, China, 4Russell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, Baltimore, MD, United States, 5F.M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Research Institute, Baltimore, MD, United States

On-resonance variable delay multiple pulse (onVDMP) CEST MRI was applied to detect dynamic D-glucose enhanced signal in brain parenchyma and CSF of 6- and 16-month old APP/PS1 AD mice. A significantly slower D-glucose clearance from CSF was observed in young AD mice compared to age-matched wild type (WT) mice. Moreover, a reduced D-glucose uptake was observed both in parenchyma and CSF of old APP/PS1 mice. D-glucose kinetics detected by onVDMP can be used to assess the alterations in D-glucose uptake and clearance in AD and in the course of AD progression at 3T, a clinical relevant MRI field.

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