Abstract #0212

Dynamic glucose enhanced (DGE) MRI at 3T detects alterations in glucose uptake and clearance in young and old Alzheimer’s mice

Jianpan Huang¹, Xiongqi Han¹, Celia M. Dong², Gerald W. Y. Cheng³, Kai-Hei Tse³, Lin Chen^4,5, Joseph H. C. Lai¹, Ed X. Wu², Peter C. M. van Zijl^4,5, Jiadi Xu^4,5, and Kannie W. Y. Chan^1,4

¹Department of Biomedical Engineering, City University of Hong Kong, Hong Kong, China, ²Department of Electrical and Electronic Engineering, The University of Hong Kong, Hong Kong, China, ³Department of Health Technology and Informatics, The Hong Kong Polytechnic University, Hong Kong, China, ⁴Russell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, Baltimore, MD, United States, ⁵F.M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Research Institute, Baltimore, MD, United States

On-resonance variable delay multiple pulse (onVDMP) CEST MRI was applied to detect dynamic D-glucose enhanced signal in brain parenchyma and CSF of 6- and 16-month old APP/PS1 AD mice. A significantly slower D-glucose clearance from CSF was observed in young AD mice compared to age-matched wild type (WT) mice. Moreover, a reduced D-glucose uptake was observed both in parenchyma and CSF of old APP/PS1 mice. D-glucose kinetics detected by onVDMP can be used to assess the alterations in D-glucose uptake and clearance in AD and in the course of AD progression at 3T, a clinical relevant MRI field.

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