Abstract #0213

Assessing White Matter Microstructural Changes Associated with Mild Cognitive Impairment using Laplacian-Regularized MAP MRI

Jason F. Moody¹, Douglas C. Dean III^1,2,3, Steven R. Kecskemeti³, Jennifer M. Oh⁴, Nagesh Adluru³, Sterling C. Johnson^4,5, Barbara B. Bendlin⁴, and Andrew L. Alexander^1,2,3,6

¹Department of Medical Physics, University of Wisconsin-Madison, Madison, WI, United States, ²Department of Pediatrics, University of Wisconsin-Madison, Madison, WI, United States, ³Waisman Center, University of Wisconsin-Madison, Madison, WI, United States, ⁴Wisconsin Alzheimer’s Disease Research Center, University of Wisconsin-Madison, Madison, WI, United States, ⁵Geriatric Research Education and Clinical Center, Middleton Memorial VA Hospital, University of Wisconsin-Madison, Madison, WI, United States, ⁶Department of Psychiatry, University of Wisconsin-Madison, Madison, WI, United States

We implement Laplacian-regularized MAP MRI to investigate distinct white matter (WM) microstructural changes associated with mild cognitive impairment (MCI).

Comparisons of diffusion parameters (via TBSS) between healthy controls and MCI patients revealed significant group differences in a wide variety of WM pathways previously shown to be altered in MCI and Alzheimer’s Dementia (AD). In particular, the MCI group exhibited WM clusters with lower return to origin probability (RTOP) and return to plane probability (RTPP) magnitudes, suggesting structurally affected axons in those tracts.

Our findings provide an early quantitative framework for identifying specific WM microstructural deficiencies characteristic of MCI and AD.

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