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Abstract #0214

Assessment of Intracranial Vascular Flow Oscillations in Alzheimer’s Disease using Real Time 4D Flow MRI 

Leonardo A Rivera-Rivera1, Laura B Eisenmenger2, Sterling C Johnson3, and Kevin M Johnson1,2
1Department of Medical Physics, University of Wisconsin - Madison, Madison, WI, United States, 2Department of Radiology, University of Wisconsin - Madison, Madison, WI, United States, 3Department of Medicine, University of Wisconsin - Madison, Madison, WI, United States

Microvascular oscillations have been speculated to be markers of autoregulation and to be driving forces of glymphatic clearance of interstitial fluid, Aβ, and other soluble metabolites of the brain. To probe spontaneous low frequency oscillations (LFO) in the brain vasculature, measures of blood flow variance during several minutes might hold potential. In this study, we investigated induced LFOs in blood flow with 4D flow using 3D radial sampling and low-rank regularization for real time blood flow variance estimates. Preliminary results showed significant increased blood flow fluctuations in age-matched controls compared to AD subjects.

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