Meeting Banner
Abstract #0215

Fast 3D High-Resolution Metabolic Imaging in Alzheimer's Disease using SPICE

Jialin Hu1, Miao Zhang2, Rong Guo3,4, Yudu Li3,4, Wanqing Sun1, Danni Wang1, Hui Huang1, Yibo Zhao3,4, Ziyu Meng1,3, Biao Li2, Jun Liu5, Binyin Li5, Jie Luo1, Zhi-Pei Liang3,4, and Yao Li1
1Institute for Medical Imaging Technology, School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai, China, 2Department of Nuclear Medicine, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China, 3Beckman Institute for Advanced Science and Technology, University of Illinois at Urbana-Champaign, Urbana, IL, United States, 4Department of Electrical and Computer Engineering, University of Illinois at Urbana-Champaign, Urbana, IL, United States, 5Department of Neurology and Institute of Neurology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China

As a progressive neurodegenerative disease, early diagnosis of Alzheimer’s disease (AD) is important but remains difficult. MRSI is a useful tool for detecting neurometabolic alterations in AD, but most studies were limited by using single-slice or single-voxel techniques with low spatial resolution and long data acquisition time. In this study, we performed 3D MRSI of AD patients at a nominal spatial resolution of 2.0 × 3.0 × 3.0 mm3 in a 7-min scan using a new technique called SPICE (SPectroscopic Imaging by exploiting spatiospectral CorrElation). Our experimental results showed noticeable neurometabolic changes in AD patients.

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.

Keywords