As a progressive neurodegenerative disease, early diagnosis of Alzheimer’s disease (AD) is important but remains difficult. MRSI is a useful tool for detecting neurometabolic alterations in AD, but most studies were limited by using single-slice or single-voxel techniques with low spatial resolution and long data acquisition time. In this study, we performed 3D MRSI of AD patients at a nominal spatial resolution of 2.0 × 3.0 × 3.0 mm3 in a 7-min scan using a new technique called SPICE (SPectroscopic Imaging by exploiting spatiospectral CorrElation). Our experimental results showed noticeable neurometabolic changes in AD patients.