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Abstract #0216

Progressive memory circuit impairments along with Alzheimer’s disease neuropathology spread: evidence from in vivo neuroimaging

Shuyue Wang1, Kaicheng Li1, Xiao Luo1, Qingze Zeng1, Yeerfan Jiaerken1, Xiaopei Xu1, Yong Zhang2, Peiyu Huang1, and Minming Zhang1
1The 2nd Affiliated Hospital of Zhejiang University, School of Medicine, Hangzhou, China, 2GE Healthcare, Shanghai, China

Along with Alzheimer’s disease (AD) continuum, AD neuropathologies propagate trans-neuronally, causing the memory circuit disorganization. The ‘misfolded tau protein propagation theory’ indicates that tau pathology spread through synaptic connectivity and cause the structural impairments. Here, we hypothesized that HP is the first to suffer from AD neuropathology, then followed by the connected tract and downstream cortex. We defined the memory circuit as the hippocampus (HP), cingulum-angular bundles (CAB), and precuneus cortex, respectively representing the starting point, core connecting fibre and connected downstream cortex. Our results support the tau propagation theory in the memory circuit.

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