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Abstract #0217

Association of Hippocampus Fimbria Iron level measured by QSM with AD stages, Hippocampus Atrophy and Aging

Chun Ki Franklin Au1, Jill Abrigo1, Jack Lee2, Chunlei Liu3, Wing Chi Lisa Au4, Queenie Chan5, Qianyun Maxine Chen1, Chung Tong Vincent Mok4, and Weitian Chen1
1Department of Imaging and Interventional Radiology, The Chinese University of Hong Kong, Hong Kong, Hong Kong, 2Centre For Clinical Research And Biostatistics, Centre for Clinical Research and Biostatistics, The Chinese University of Hong Kong, Hong Kong, Hong Kong, 3Department of Electrical Engineering and Computer Sciences, University of California, Berkeley, USA, CA, United States, 4Division of Neurology, The Chinese University of Hong Kong, Hong Kong, Hong Kong, 5Philips, Hong Kong, Hong Kong

Iron accumulation has been reported in specific brain regions of Alzheimer disease patients. In this study, we used Quantitative Susceptibility Mapping to show iron deposition in hippocampal fimbria and its strong correlation with hippocampus volume and AD stages. Our result might provide further insight of potential disconnection injury in AD pathophysiology.

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