Abstract #0217

Association of Hippocampus Fimbria Iron level measured by QSM with AD stages, Hippocampus Atrophy and Aging

Chun Ki Franklin Au¹, Jill Abrigo¹, Jack Lee², Chunlei Liu³, Wing Chi Lisa Au⁴, Queenie Chan⁵, Qianyun Maxine Chen¹, Chung Tong Vincent Mok⁴, and Weitian Chen¹

¹Department of Imaging and Interventional Radiology, The Chinese University of Hong Kong, Hong Kong, Hong Kong, ²Centre For Clinical Research And Biostatistics, Centre for Clinical Research and Biostatistics, The Chinese University of Hong Kong, Hong Kong, Hong Kong, ³Department of Electrical Engineering and Computer Sciences, University of California, Berkeley, USA, CA, United States, ⁴Division of Neurology, The Chinese University of Hong Kong, Hong Kong, Hong Kong, ⁵Philips, Hong Kong, Hong Kong

Iron accumulation has been reported in specific brain regions of Alzheimer disease patients. In this study, we used Quantitative Susceptibility Mapping to show iron deposition in hippocampal fimbria and its strong correlation with hippocampus volume and AD stages. Our result might provide further insight of potential disconnection injury in AD pathophysiology.

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