Abstract #0218

Quantitative assessment of cerebrovascular reactivity in older individuals: relationship to diagnosis, cognition and physical function

Sandeepa Sur¹, Zixuan Lin¹, Yang Li¹, Sevil Yasar², Paul Rosenberg³, Abhay Moghekar⁴, Shruti Agarwal¹, Xirui Hou¹, Rita Kalyani⁵, Kaisha Hazel¹, George Pottanat¹, Cuimei Xu¹, Peter van Zijl⁶, Jay Pillai⁷, Peiying Liu¹, Marilyn Albert⁴, and Hanzhang Lu¹

¹Department of Radiology, Johns Hopkins University, Baltimore, MD, United States, ²Department of Gerontology, Johns Hopkins University, Baltimore, MD, United States, ³Department of Psychiatry and Behavioral Sciences, Johns Hopkins University, baltimore, MD, United States, ⁴Department of Neurology, Johns Hopkins University, Baltimore, MD, United States, ⁵Department of Medicine, Johns Hopkins University, Baltimore, MD, United States, ⁶F.M. Kirby Research Center, Kennedy Krieger Institute, baltimore, MD, United States, ⁷Department of Neurosurgery, Johns Hopkins University, Baltimore, MD, United States

This study addresses the question, whether quantitative cerebrovascular reactivity (CVR) is a potential vascular biomarker in dementia with Alzheimer’s and vascular pathologies. This was tested in a cross-sectional study, where CBF-CVR assessed via Phase-Contrast-MRI during a CO₂ breathing-challenge predicted cognitive and functional performance, disease-severity, and diabetes-risk, in 67 normal and mild-cognitive-impairment subjects. The performance and severity relationships remained robust after adjusting for Alzheimer’s disease and competing vascular markers. These findings suggest that quantitative CBF-CVR has potential as a sensitive biomarker for early changes in cognitive and functional performance, and of disease severity in dementia, independent of Alzheimer’s disease.

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