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Abstract #0218

Quantitative assessment of cerebrovascular reactivity in older individuals: relationship to diagnosis, cognition and physical function

Sandeepa Sur1, Zixuan Lin1, Yang Li1, Sevil Yasar2, Paul Rosenberg3, Abhay Moghekar4, Shruti Agarwal1, Xirui Hou1, Rita Kalyani5, Kaisha Hazel1, George Pottanat1, Cuimei Xu1, Peter van Zijl6, Jay Pillai7, Peiying Liu1, Marilyn Albert4, and Hanzhang Lu1
1Department of Radiology, Johns Hopkins University, Baltimore, MD, United States, 2Department of Gerontology, Johns Hopkins University, Baltimore, MD, United States, 3Department of Psychiatry and Behavioral Sciences, Johns Hopkins University, baltimore, MD, United States, 4Department of Neurology, Johns Hopkins University, Baltimore, MD, United States, 5Department of Medicine, Johns Hopkins University, Baltimore, MD, United States, 6F.M. Kirby Research Center, Kennedy Krieger Institute, baltimore, MD, United States, 7Department of Neurosurgery, Johns Hopkins University, Baltimore, MD, United States

This study addresses the question, whether quantitative cerebrovascular reactivity (CVR) is a potential vascular biomarker in dementia with Alzheimer’s and vascular pathologies. This was tested in a cross-sectional study, where CBF-CVR assessed via Phase-Contrast-MRI during a CO2 breathing-challenge predicted cognitive and functional performance, disease-severity, and diabetes-risk, in 67 normal and mild-cognitive-impairment subjects. The performance and severity relationships remained robust after adjusting for Alzheimer’s disease and competing vascular markers. These findings suggest that quantitative CBF-CVR has potential as a sensitive biomarker for early changes in cognitive and functional performance, and of disease severity in dementia, independent of Alzheimer’s disease.

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