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Abstract #0219

The neurocognitive effects of VSOP training in mild cognitive impairment (CogTE study): A phase-II clinical trial

Feng Vankee Lin1
1Center for Advanced Imaging and Neurophysiology, University of Rochester, ROCHESTER, NY, United States

The current lack of effective pharmacological treatments for managing clinical symptoms in Alzheimer’s dementia highlights the urgent need for developing non-pharmacological interventions in the field. Here we report a phase II randomized controlled trial that examined the immediate and mid-term effect of a cognitive process based training on multiple cognitive domains in mild cognitive impairment. We found robust intervention effect on processing speed/attention and working memory. These cognitive improvements were associated with both activation changes and network changes involving ACC, a hub for maintaining successful cognitive aging. These results provide new insights about non-pharmacological interventions in preventing dementia.

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