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Abstract #0220

Evaluation of neuroinflammation in Alzheimer’s disease on human subjects using third-generation TSPO ligand [18F]-GE180

Zhengshi Yang1, Karthik Sreenivasan1, Xiaowei Zhuang1, Aaron Ritter1, Jessica Caldwell1, Sarah J Banks2, Virendra Mishra1, Marwan Sabbagh1, Dietmar Cordes1,3, and Jeffrey Cummings1,4
1Cleveland Clinic Lou Ruvo Center for Brain Health, Las Vegas, NV, United States, 2Department of Neuroscience, University of California, San Diego, CA, United States, 3Department of Psychology and Neuroscience, University of Colorado, Boulder, CO, United States, 4Department of Brain Health, School of Integrated Health Sciences, University of Nevada, Las Vegas, NV, United States

Inflammatory reactions contribute to disease progression and severity of Alzheimer’s disease (AD). While multiple animal studies have suggested that increased neuroinflammation occurs in AD, few studies have investigated neuroinflammation in human subjects. This is the first study using the third-generation TSPO ligand [18F]-GE180 to evaluate the neuroinflammation in AD on human subjects. Our study suggests that neuroinflammation accumulates together with amyloid deposition and reaches a plateau when the regional amyloid SUVR reaches 1.1 threshold. Compared to amyloid pathology, neuroinflammation is more closely related to hyperconnectivity in MCI/AD subjects.

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