Inflammatory reactions contribute to disease progression and severity of Alzheimer’s disease (AD). While multiple animal studies have suggested that increased neuroinflammation occurs in AD, few studies have investigated neuroinflammation in human subjects. This is the first study using the third-generation TSPO ligand [18F]-GE180 to evaluate the neuroinflammation in AD on human subjects. Our study suggests that neuroinflammation accumulates together with amyloid deposition and reaches a plateau when the regional amyloid SUVR reaches 1.1 threshold. Compared to amyloid pathology, neuroinflammation is more closely related to hyperconnectivity in MCI/AD subjects.
How to access this content:
For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.
After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.
After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.
Keywords