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Abstract #0221

Deciphering transcriptomic basis of the human brain structural connectome in the 3rd trimester

Chenying Zhao1,2, Gabriel Santpere3, David Andrijevic3, Minhui Ouyang1, Nenad Sestan3, and Hao Huang1,4
1Department of Radiology, Children's Hospital of Philadelphia, Philadelphia, PA, United States, 2Department of Bioengineering, School of Engineering and Applied Science, University of Pennsylvania, Philadelphia, PA, United States, 3Department of Neuroscience and Kavli Institute for Neuroscience, Yale School of Medicine, New Haven, CT, United States, 4Department of Radiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, United States

Dramatic development of brain connectome takes place during the 3rd trimester, mediated by transcriptome. Transcriptome is complete set of gene-expressed mRNAs and is heterogeneous across brain regions and dynamic throughout development. The transcriptomic basis of structural connectome in this critical developmental stage is unknown. In this study, we identified transcription genes most significantly correlated to nodal efficiency and degree centrality of macroscale structural connectome based on diffusion MRI of 77 preterm brains and over 60,000 quantified transcriptomes. These identified transcription genes such as MYRF regulating oligodendrocyte differentiation and myelination may shed light into the transcriptomic basis of structural connectome development.

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