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Abstract #0225

Multivariate Evaluation of White Matter Maturation on Neonates and Toddlers by Diffusion Kurtosis Imaging with Mahalanobis Distance

Xianjun Li1, Miaomiao Wang1, Fan Wu1, Qinli Sun1, Heng Liu1, Yuli Zhang1, Mengxuan Li1, Chao Jin1, Congcong Liu1, Xiaocheng Wei1, and Jian Yang1
1Department of Radiology, the First Affiliated Hospital of Xi’an Jiaotong University, Xi'an, China

Mahalanobis distance is a feasible multivariate approach. This work compared performances of Mahalanobis distances based on different combinations of metrics in assessing the white matter maturation on neonates and toddlers. Mahalanobis distance based on the combination of diffusion tensor and kurtosis tensor metrics demonstrated various advantages: stronger correlation with the postmenstrual age and higher developmental speeds could be revealed; distances from the developing to the adult brains and the changes from neonates to toddlers were enlarged. Results in the current work suggest that diffusion kurotsis imaging with the Mahalanobis distance would benefit the characterization of white matter maturation.

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