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Abstract #0226

Prematurity-related brain injuries disrupt thalamocortical reciprocal growth

Audrey Yin1, Mengting Liu1, Arthur W. Toga1, Duan Xu2, James Barkovich2, and Hosung Kim1
1USC Stevens Neuroimaging and Informatics Institute, Keck School of Medicine of USC, University of Southern California, Los Angeles, CA, United States, 2Department of Radiology and Biomedical Imaging, UCSF School of Medicine, University of California, San Francisco, San Francisco, CA, United States

Prematurity-related injuries often result in aberrant brain maturation, specifically on peri-thalamic white matter. We investigated the effects of these injuries on the intra-thalamic tissue integrity and on thalamocortical connectivity. We found that injuries did not substantially affect thalamic volume or thalamic DTI parameters, but did have a substantial effect on the correlative growth between the thalamus and cortex. This implies that brain injuries disrupt the reciprocal development of the thalamus and cortex, which may indicate abnormal thalamocortical connectivity.

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