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Abstract #0230

Longitudinal Changes of the Extremely Preterm Brain from Age 10 to Age 15: Myelination and Hydration.

Ryan McNaughton1, Hernan Jara2, Xin Zhang1, Mina Botros2, Robert M Joseph2, Asim Z Mian2, Laurie Douglass2, Karl Kuban2, Rebecca C Fry3, and Michael O'Shea3
1Mechanical Engineering, Boston University, Boston, MA, United States, 2Boston University Medical Center, Boston, MA, United States, 3University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, NC, United States

Purpose: To identify new qMRI markers for assessing changes in hydration and myelination during development of the extremely preterm (EP) brain. Methods: Quantitative MR algorithms create maps of the transverse relaxation time (T2) and normalized proton density (PD) for 7 EP born individuals using MR images obtained at age 10 and age 15 years. Results: White and grey matter of the EP brain demonstrate increases in proton density and significant decreases in tissue T2. Conclusion: Decreases in T2 potentially describes the evolution of a more myelin rich environment with age, motivating a new method to assess myelination during brain development.

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