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Abstract #0231

Towards clinical implementation of multi-shell diffusion MRI: visual pathway investigation in paediatric epilepsy surgery

Luis Miguel Lacerda1, Jon Clayden1, Sian Handley2, Martin Tisdall3, Enrico Kaden4, Gavin Winston5, Alki Liasis2,6, Helen Cross7, and Chris Clark1
1Developmental Imaging and Biophysics Section, UCL Great Ormond Street Institute of Child Health, London, United Kingdom, 2Clinical and Academic Department of Ophthalmology, Great Ormond Street Hospital for Children NHS Foundation Trust, London, United Kingdom, 3Neurosurgery, Great Ormond Street Hospital for Children NHS Foundation Trust, London, United Kingdom, 4Centre for Medical Image Computing, University College London, London, United Kingdom, 5Department of Clinical and Experimental Epilepsy, UCL Institute of Neurology, London, United Kingdom, 6University of Pittsburgh Medical Centre, Children’s Hospital of Pittsburgh, Pittsburgh, PA, United States, 7Clinical Neurosciences, UCL Great Ormond Street Institute of Child Health, London, United Kingdom

We used multi-shell diffusion imaging to investigate differences in the visual pathways of children undergoing epilepsy surgery and demonstrated its potential for clinical practice. In particular, we compared the traditional Diffusion Tensor Imaging model with the Spherical Mean Technique model and evaluated its potential to produce measures of tissue microstructure not confounded by orientation effects in both a healthy and patient population. Furthermore, we explored the effect of brain surgery and applied Constrained Spherical Deconvolution derived tractography to determine the frequency and influence of the extent and location of resection on the integrity of the visual system after the operation.

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