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Abstract #0237

Feasibility of oscillating and pulsed gradient diffusion MRI to assess neonatal hypoxia-ischemia on clinical system

Fusheng Gao1, Xiaoxia Shen1, Hongxi Zhang1, Yi Zhang2, Xiaolu Ma1, Jiangyang Zhang3, and Dan Wu2
1Children's Hospital, Zhejiang University School of Medicine, Hangzhou, China, 2Key Laboratory for Biomedical Engineering of Ministry of Education, College of Biomedical Engineering & Instrument Science, Zhejiang University, Hangzhou, China, 3Department of Radiology, New York University School of Medicine, New York, NY, United States

Despite the success of diffusion time (td) dependent diffusion MRI in simulation and preclinical studies, clinical applications of the technique are challenged by difficulties in accessing short td, limited primarily by the clinical gradient system. This study demonstrated the feasibility of td-dependent dMRI using oscillating and pulsed gradients on a 3T clinical system to investigate neonatal hypoxic-ischemic encephalopathy (HIE). Results demonstrated that the td-dependency (ΔMD) increased in the deep gray matter of infants during the first year. In HIE patients, ΔMD increased in the basal ganglia of the severe and moderate HIE, as well as in the penumbra of lesions.

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