Synopsis: As a noninvasive imaging biomarker, phosphorous magnetic resonance spectroscopy (31PMRS) has traditionally been used to measure the metabolic response of exercised skeletal muscle in humans and has contributed immensely to the vital understanding of muscle energetics. However, due to lack of spatial resolution in 31PMRS, it is difficult to resolve the intermuscular variabilities of creatine kinase kinetics. In this study we demonstrate that with proper placement of surface coil in a mild exercise study, the recovery constant for PCr determined from 31PMRS matches well with recovery constant measured from CrCEST using a volume coil for the same muscle group.
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